
A Blood Pressure Drug, a Diabetes Drug, and What Their Gene Expression Profiles Have in Common
We were testing protoXell's drug similarity search and wanted to try it on a case where we already had some idea of the answer. If the tool is useful, it should be able to find a repurposing story that has been tested in the clinic, without us pointing it there. Verapamil was a good fit. It is a calcium channel blocker that has been used for decades for blood pressure and heart rhythm problems, and over the past several years it has been tested in diabetes. A small 2018 trial in adults with new









